Diagenetic palaeotemperatures determined from aqueous fluid inclusions can be affected by re-equilibration during burial heating. Calculations based on the observed behaviour of inclusions in fluorite under external confining pressure allows prediction of the temperatures and depths of burial necessary to initiate re-equilibration of aqueous inclusions in the common size range 40 to 4 µm. Heating of 20° to 60°C over the initial trapping temperature may cause errors of 10° to 20°C in the homogenization temperature. This suggests re-equilibration may cause aqueous inclusions in carbonates to yield a poor record of their low-temperature history, but a useful record of the maximum temperature experienced by the host rock. Previous work suggests inclusions containing petroleum fluids will be less susceptible to re-equilibration.