Favourability of uranium mineralization in six tertiary granitic plutons of the Alaska Range in the Talkeetna and Mt McKinley quadrangles was studied. The uranium concentrations of drainage sediment samples, which were collected and analysed by the Los Alamos Scientific Laboratory for the National Uranium Resources Evaluation, were statistically evaluated and compared to those of the surrounding area using factor and cluster analyses. The results of this study suggest that five of the six plutons under consideration are likely to contain uranium mineralization. These plutons are probably a potential source rock for uranium in the region.