The Caledonian fold belt of East Greenland contains calc-alkaline granite (sensu lato) intrusions with ages ranging from c.2000 Ma to c.350 Ma. The Proterozoic granites have low U contents and the pre-Devonian Caledonian granites contents of U corresponding to the clarke value for U in granites. Some aspects of the geochemistry of U are discussed using U-K/Rb, U-Sr, U-Zr, and U-Th diagrams. Secondary enrichment and mineralization occurs in fractured and hydrothermally altered granites and rhyolites situated in or near a major NNE fault zone. The U is associated with iron oxides or hydrocarbons. It is suggested that the source of the mineralization was Devonian acid magma, which also acted as a heat source for circulating hydrothermal fluids.